What is CREON?

CREON (pancrelipase) is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes. This condition is called EPI (exocrine pancreatic insufficiency) and may be due to cystic fibrosis, chronic pancreatitis (swelling of the pancreas that lasts a long time), pancreatectomy (removal of some or all of the pancreas), or other conditions. Taken as prescribed, CREON replaces enzymes that your pancreas isn’t making, helping you digest fats, proteins, and carbohydrates (sugars) in food.

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Over 1 million EPI patients have been prescribed CREON

Number one prescribed EPI treatment icon

CREON is the #1
prescribed EPI treatment

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Nearly 9 out of 10 GI specialists prescribe CREON more than any other PERT*

*Per Oct '18-Sept '19 analysis of 10,053 GI specialists from IQVIA Xponent. 86% of surveyed GI specialists had >50% of their PERT prescriptions filled as CREON.

GI = gastrointestinal.

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How should I take CREON?

If your doctor prescribes CREON, they will choose a dose that is specific for you, based on things like your body weight and your diet—so make sure you take CREON exactly as your doctor tells you. It's also important to remember that in order for CREON to work properly, it should always be taken with food.


Take it. Track it. Talk about it.

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Take CREON every time you eat

Take CREON every time you eat, whether it’s a full meal or a snack. Don’t forget to take CREON with you when you’re on the go—especially when you’re eating out. Always take CREON with enough liquid to swallow your dose. Do not crush or chew CREON.

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Track your diet symptoms

Keep track of what you are eating and how you are feeling. Tracking your diet and symptoms will help your doctor determine if your CREON dose needs to be adjusted.

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Talk with your doctor

Communicate with your doctor and care team regularly, and share how you're feeling. It's important to schedule follow-up visits to maintain an ongoing conversation about your symptoms.

Question circle

Answer this question so we can help you find what you're looking for:

How long have you been taking CREON?

You answered "0 to 3 months"

Record your treatment progress and daily routine using the Treatment Tracker.

Learn about the financial, multivitamin, and educational resources available through CREON On Course.

You answered "3 months to a few years"

Get tools and tips to help you start and stay on track with your CREON treatment plan.

Read about how to make healthy diet and lifestyle choices with EPI.

You answered "Whole life"

Learn about the financial, multivitamin, and educational resources available through CFCareForward.

Hear people with EPI due to cystic fibrosis talk about their experiences with CREON.

You answered "Not prescribed CREON"

Fill out the Doctor Discussion Guide to help you communicate your symptoms to your doctor.

Learn how CREON works to break down food in people with EPI.

- CAMILLE E. EPI patient

My life has changed since being diagnosed with EPI, but it has not stopped me from living. I still watch what I eat and have a healthy, balanced diet and take my CREON.

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Your quick guide to EPI and CREON

It may seem like there's a lot to learn about EPI (exocrine pancreatic insufficiency) and CREON, but this brochure can help you navigate different topics and provide you with the answers you need as you're starting treatment.

Answers to frequently asked questions

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How CREON works

CREON replaces digestive enzymes that your pancreas no longer makes, helping you break down your food.