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CREON (pancrelipase) is a prescription medicine used to treat EPI (exocrine pancreatic insufficiency). EPI is a condition where the pancreas doesn't release enough digestive enzymes to break down food. CREON works by replenishing the missing enzymes.

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What is EPI?

EPI is a condition that occurs when the pancreas doesn’t make enough digestive enzymes.

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Getting started with CREON

Get tools and tips to help you start and stay on track with your CREON treatment plan.

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Real patient stories

Hear what patients have to say about EPI and treatment with CREON.

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Saving on CREON

Find out if you’re eligible to pay as little as $5 (or less) for your monthly CREON prescription.*

Answer this question so we can help you find what you're looking for:

How long have you been taking CREON?

You answered Less than 1 month

Get tools and tips to help you start and stay on track with your CREON treatment plan.

Discover what CREON is doing inside your body after you take it.

You answered 1 – 3 months

Record your treatment progress and daily routine using the Treatment Tracker.

CREON Complete offers support and resources for your treatment journey.

You answered over 3 months

CREON Complete offers support and resources for your treatment journey.

Learn how healthy eating, vitamins and supplements, and lifestyle changes can help you manage your EPI.

You answered Not currently prescribed CREON

Take the EPI Symptom Quiz or download a discussion guide to help track your symptoms.

EPI is a condition that occurs when the pancreas doesn’t make enough digestive enzymes.

Supporting you every step of the way

CREON's patient support programs provide you with:

  • Financial savings on CREON*
  • Multivitamins and nutritional products at no charge*
  • Educational resources about EPI and CREON

*Eligibility: Available to patients with commercial prescription insurance coverage for CREON® (pancrelipase) who meet eligibility criteria. Neither co-pay assistance nor multivitamins/nutritional supplements are available to patients receiving prescription reimbursement under any federal, state, or government-funded insurance programs (for example, Medicare [including Part D], Medicare Advantage, Medigap, Medicaid, TRICARE, Department of Defense, or Veterans Affairs programs) or where prohibited by law. Offers subject to change or discontinuance without notice. Restrictions, including monthly maximums, may apply. This is not health insurance. For full Terms and Conditions, visit

 or call 1-844-662-7366 for additional information. For full Terms and Conditions for CREON CF patients, visit

 or call 1-855-227-3493 for additional information. To learn about AbbVie’s privacy practices and your privacy choices, visit