Hold the capsule upright so that you can see the word CREON on the capsule.
Giving CREON to your infant up to 12 months old
CREON may be prescribed to infants who have EPI (exocrine pancreatic insufficiency) due to cystic fibrosis (CF). If you’re caring for an infant who needs to take CREON, watch the video for tips on giving enzymes to a baby.
Carefully twist off the top portion of the capsule.
Sprinkle the contents from the capsule directly into your infant’s mouth, or mix the contents in a small amount of room-temperature acidic soft food such as applesauce or jarred baby food. Do not mix CREON with formula or bottled breast milk. If you sprinkle CREON on soft food, feed it to your child immediately. Do not store leftover food mixed with CREON.
Give your child enough liquid to completely swallow the CREON contents or the CREON and food mixture. Check inside your baby’s mouth to ensure that he or she has swallowed all the capsule contents. To avoid irritation, care should be taken to ensure no medicine is left in the mouth. Refer to the CREON Medication Guide for additional instructions.
Key points to remember when giving CREON to infants:
- Give CREON right before every feeding of formula, breast milk, or food.
- Do not crush or chew CREON capsules or their contents.
- Do not mix the CREON capsule contents directly into formula or breast milk.
- Give your infant enough formula or breast milk to help him or her completely swallow the CREON capsule contents or CREON food mixture.
- Check inside your baby’s mouth to ensure that he or she has swallowed all the CREON capsule contents. To avoid irritation, care should be taken to ensure no medicine is left in the mouth.
- If you sprinkle CREON on food, give the CREON and food mixture to your infant right away. Do not save leftover food mixed with CREON.
CREON may increase your chance of fibrosing colonopathy, a rare bowel disorder. Tell your doctor if you have a history of intestinal blockage or scarring or thickening of your bowel wall; if you are allergic to pork; or if you have gout, kidney problems, or worsening of painful, swollen joints. Call your doctor if you have any unusual or severe gastrointestinal symptoms or allergic reactions. Take CREON as directed by your doctor and always with food. Do not chew capsules as this may cause mouth irritation. Other side effects may include blood sugar changes, gas, dizziness, sore throat, and cough. These are not all the side effects of CREON.
Answers to frequently asked questions
The most common side effects include increased blood sugar levels (hyperglycemia) or decreased blood sugar levels (hypoglycemia), pain in your stomach area, frequent or abnormal bowel movements, gas, vomiting, dizziness, or sore throat and cough. Always carefully discuss the risks and benefits of CREON with your doctor.
- Store CREON at room temperature, 59°F to 77°F (15°C to 25°C). Avoid heat.
- You may store CREON at a temperature between 77°F and 104°F (25°C to 40°C) for up to 30 days. Throw away any CREON that has been stored at these temperatures for more than 30 days.
- Keep CREON in a dry place and in the original container.
- After you open the bottle, keep it closed tightly between uses to protect against moisture.
- Keep CREON out of the reach of children.