Narrator:

CREON, pancrelipase, is a prescription medicine that works by replacing the pancreatic enzymes that are missing in people who have EPI...

....due to cystic fibrosis, chronic pancreatitis (which is the swelling of the pancreas that lasts a long time), pancreatectomy (which is the removal of some or all of the pancreas), or other conditions.

CREON needs to be taken with every meal and snack, and there’s a good reason why.

Your pancreas PRODUCES enzymes every time you eat...

...so CREON is used to REPLACE those enzymes every time you eat.

It’s important to always take CREON with a meal or snack and enough liquid to swallow the capsules completely.

Also, be sure not to chew or crush CREON capsules.

In order to work, CREON needs to get to the right location in the body to do its job...

...and it needs to travel down the digestive tract with your food.

Timing is key. CREON and food need to get on board together...

...so that they reach their destination together.

CREON has a special coating to make sure it reaches the starting point of your small intestine (which is called your duodenum).

Your duodenum is where CREON releases enzymes to break down the fats, proteins, and carbohydrates in your food...

...so that they can be absorbed and used by your body.

So remember, if you have EPI, CREON can help break down your food so that nutrients can get to their final destination.

Use

CREON^® (pancrelipase) is a prescription medicine used to treat people who cannot digest food normally because their pancreas does not make enough enzymes.

Important Safety Information
What is the most important information I should know about CREON?
CREON may increase your chance of having a rare bowel disorder called fibrosing colonopathy. The risk of having this condition may be reduced by following the dosing instructions that your healthcare professional (HCP) gave you. Call your HCP right away if you have any unusual or severe: stomach area (abdominal) pain, bloating, trouble passing stool, nausea, vomiting, or diarrhea.

What should I tell my HCP before taking CREON?
Before taking CREON, tell your HCP about all the medicines you take and all your medical conditions, including if you are allergic to pork (pig) products; have a history of intestinal blockage or scarring or thickening of your bowel wall (fibrosing colonopathy), gout, kidney disease, or high blood uric acid (hyperuricemia); or are pregnant, plan to become pregnant, are breastfeeding, or plan to breastfeed.

How should I take CREON?
Take CREON exactly as your HCP tells you. Always take CREON with a meal or snack and enough liquid to swallow CREON completely. Do not crush or chew the CREON capsule or its contents, as this may cause irritation in your mouth or change the way CREON works in your body. Talk to your HCP or consult the CREON Medication Guide for how to take CREON if you have trouble swallowing capsules.

What are the possible side effects of CREON?
CREON may cause additional serious side effects, including:

• Increase in blood uric acid levels (hyperuricemia), including pain, stiffness, redness or swelling of your joints.
• Allergic reactions, including trouble with breathing, skin rashes, swollen lips, or itching.

Call your HCP right away if you have any of these symptoms.

The most common side effects of CREON include blood sugar increase (hyperglycemia) or decrease (hypoglycemia), pain in your stomach, frequent or abnormal bowel movements, gas, vomiting, dizziness, sore throat, and cough.

CREON and other pancreatic enzyme products are made from the pancreas of pigs, the same pigs people eat as pork. These pigs may carry viruses. Although it has never been reported, it may be possible for a person to get a viral infection from taking pancreatic enzyme products that come from pigs.

These are not all the possible side effects of CREON. For more information, ask your HCP or pharmacist.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1‑800‑FDA‑1088.

If you are having difficulty paying for your medicine, AbbVie may be able to help. Visit AbbVie.com/PatientAccessSupport to learn more.